While HIV treatment was made more affordable in recent years, some people living with HIV are not in the ART care chain (UNAIDS, 2020). This causes the issue of retention in ART for PLHIV. This study aims to understand social logics of retention of PLHIV in ARV care in Côte d'Ivoire through case exploration at CSUCOM Palmeraie and FSU Affery. It is based on documentary research and an interview. The data from the study show that retention in ART care is the outcome of various relationships to care. These relationships are spatial, biological, cultural, and economic. They are manifested through the actualization of the therapeutic culture of HIV patients for their survival in their social, family and work environment. Thus, health centers consider the specificities of each PLWHIV in their management and retention approaches. This requires flexibility in access to care, considering the vulnerability and social environment of each PLWHIV.